2,160 research outputs found
The bend stiffness of S-DNA
We formulate and solve a two-state model for the elasticity of nicked,
double-stranded DNA that borrows features from both the Worm Like Chain and the
Bragg--Zimm model. Our model is computationally simple, and gives an excellent
fit to recent experimental data through the entire overstretching transition.
The fit gives the first value for the bending stiffness of the overstretched
state as about 10 nm*kbt, a value quite different from either B-form or
single-stranded DNA.Comment: 7 pages, 1 figur
Nonlinear elasticity of composite networks of stiff biopolymers with flexible linkers
Motivated by recent experiments showing nonlinear elasticity of in vitro
networks of the biopolymer actin cross-linked with filamin, we present an
effective medium theory of flexibly cross-linked stiff polymer networks. We
model such networks by randomly oriented elastic rods connected by flexible
connectors to a surrounding elastic continuum, which self-consistently
represents the behavior of the rest of the network. This model yields a
crossover from a linear elastic regime to a highly nonlinear elastic regime
that stiffens in a way quantitatively consistent with experiment.Comment: 4 pages, 3 figure
Critical behaviour in the nonlinear elastic response of hydrogels
In this paper we study the elastic response of synthetic hydrogels to an
applied shear stress. The hydrogels studied here have previously been shown to
mimic the behaviour of biopolymer networks when they are sufficiently far above
the gel point. We show that near the gel point they exhibit an elastic response
that is consistent with the predicted critical behaviour of networks near or
below the isostatic point of marginal stability. This point separates rigid and
floppy states, distinguished by the presence or absence of finite linear
elastic moduli. Recent theoretical work has also focused on the response of
such networks to finite or large deformations, both near and below the
isostatic point. Despite this interest, experimental evidence for the existence
of criticality in such networks has been lacking. Using computer simulations,
we identify critical signatures in the mechanical response of sub-isostatic
networks as a function of applied shear stress. We also present experimental
evidence consistent with these predictions. Furthermore, our results show the
existence of two distinct critical regimes, one of which arises from the
nonlinear stretch response of semi-flexible polymers.
Gait monitoring: from the clinics to the daily life
Monitoring of gait in daily living allows a quantitative analysis of walking in unrestricted conditions, with many potential clinical applications. This thesis aims at addressing the limitations that still hinder the wider adoption of this approach in clinical practice, providing healthcare professionals and researchers new tools which may impact on current gait assessment procedures and improve the treatment of many diseases leading to – or generated by – mobility impairments. The thesis comprises four experimental sections:
Accuracy of commercially-available devices. Step detection accuracy in currently available physical activity monitors was assessed in healthy individuals. The best performing device was then tested in multiple sclerosis patients, showing reliability but highly speed-dependent accuracy. These findings suggest that a short set of tests performed in controlled conditions could inform researchers before starting unsupervised monitoring of gait in patients.
Differences between laboratory and free-living gait parameters. The study assessed the accuracy of two algorithms for gait event detection, and provided normative values of gait temporal parameters for healthy subjects in different environments and types of walking.
A pilot study toward clinical application. This pilot study compared laboratory based tests with daily living assessment of gait features in multiple sclerosis patients. Results provided clear evidence that in this population clinical gait tests might not represent typical gait patterns of daily living.
Analysis of free-living walking in patients with Diabetes. A systematic review is presented looking for evidence of the effectiveness of walking as physical activity to reduce inflammation. Then, cadence and step duration variability are examined during free-living walking in a group of patients with diabetes.
This thesis systematically highlighted potential and actual limitations in the use of wearable sensors for gait monitoring in daily life, providing clear practical indications and normative values which are essential for the widespread informed and effective clinical adoption of this technology
A pulsational approach to near infrared and visual magnitudes of RR Lyrae stars
In this paper we present an improved theoretical scenario concerning near
infrared and visual magnitudes of RR Lyrae variables, as based on up-to-date
pulsating models. On this basis, we revisit the case of the prototype variable
RR Lyr, showing that the parallax inferred by this new pulsational approach
appears in close agreement with HST absolute parallax. Moreover, available K
and V measurements for field and cluster RR Lyrae variables with known
reddening and metal content are used to derive a relation connecting the K
absolute magnitude to period and metallicity, as well as a new calibration of
the M_V-[Fe/H] relation. The comparison between theoretical prescriptions and
observations suggests that RR Lyrae stars in the field and in Galactic Globular
Clusters should have quite similar evolutionary histories. The comparison
between theory and observations also discloses a general agreement that
supports the reliability of current pulsational scenario. On the contrary,
current empirical absolute magnitudes based on the Baade-Wesselink (BW) method
suggest relations with a zero-point that is fainter than predicted by pulsation
models, together with a milder metallicity dependence. However, preliminary
results based on a new calibration of the BW method provided by Cacciari et al.
(2000) for RR Cet and SW And appear in a much better agreement with the
pulsational predictions.Comment: 11 pages, 9 postscript figures, accepted for publication on MNRA
Absolute Determination of the 22Na(p,g) Reaction Rate in Novae
Gamma-ray telescopes in orbit around the Earth are searching for evidence of
the elusive radionuclide 22Na produced in novae. Previously published
uncertainties in the dominant destructive reaction, 22Na(p,g)23Mg, indicated
new measurements in the proton energy range of 150 to 300 keV were needed to
constrain predictions. We have measured the resonance strengths, energies, and
branches directly and absolutely by using protons from the University of
Washington accelerator with a specially designed beamline, which included beam
rastering and cold vacuum protection of the 22Na implanted targets. The
targets, fabricated at TRIUMF-ISAC, displayed minimal degradation over a ~ 20 C
bombardment as a result of protective layers. We avoided the need to know the
stopping power, and hence the target composition, by extracting resonance
strengths from excitation functions integrated over proton energy. Our
measurements revealed that resonance strengths for E_p = 213, 288, 454, and 610
keV are stronger by factors of 2.4 to 3.2 than previously reported. Upper
limits have been placed on proposed resonances at 198-, 209-, and 232-keV. We
have re-evaluated the 22Na(p,g) reaction rate, and our measurements indicate
the resonance at 213 keV makes the most significant contribution to 22Na
destruction in novae. Hydrodynamic simulations including our rate indicate that
the expected abundance of 22Na ejecta from a classical nova is reduced by
factors between 1.5 and 2, depending on the mass of the white-dwarf star
hosting the nova explosion.Comment: 20 pages, 18 figures; shortened paper, accepted in Phys. Rev.
Cepheid variables in the LMC cluster NGC 1866. I. New BVRI CCD photometry
We report BV(RI)c CCD photometric data for a group of seven Cepheid variables
in the young, rich cluster NGC 1866 in the Large Magellanic Cloud. The
photometry was obtained as part of a program to determine accurate distances to
these Cepheids by means of the infrared surface brightness technique, and to
improve the LMC Cepheid database for constructing Cepheid PL and PLC relations.
Using the new data together with data from the literature, we have determined
improved periods for all variables. For five fundamental mode pulsators, the
light curves are now of excellent quality and will lead to accurate distance
and radius determinations once complete infrared light curves and radial
velocity curves for these variables become available.Comment: To appear in ApJ Supp., AASTeX, 24 pages, 8 tables, 8 figure
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A New Calibration Of Galactic Cepheid Period-Luminosity Relations From B To K Bands, And A Comparison To LMC Relations
Context. The universality of the Cepheid period-luminosity (PL) relations has been under discussion since metallicity effects were assumed to play a role in the value of the intercept and, more recently, of the slope of these relations. Aims. The goal of the present study is to calibrate the Galactic PL relations in various photometric bands (from B to K) and to compare the results to the well-established PL relations in the LMC. Methods. We use a set of 59 calibrating stars, the distances of which are measured using five different distance indicators: Hubble Space Telescope and revised Hipparcos parallaxes, infrared surface brightness and interferometric Baade-Wesselink parallaxes, and classical Zero-Age-Main-Sequence-fitting parallaxes for Cepheids belonging to open clusters or OB stars associations. A detailed discussion of absorption corrections and projection factor to be used is given. Results. We find no significant difference in the slopes of the PL relations between LMC and our Galaxy. Conclusions. We conclude that the Cepheid PL relations have universal slopes in all photometric bands, not depending on the galaxy under study (at least for LMC and Milky Way). The possible zero-point variation with metal content is not discussed in the present work, but an upper limit of 18.50 for the LMC distance modulus can be deduced from our data.McDonald Observator
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